Aloe macroclada: The Cellular Secret of Madagascar for Natural Regeneration

What if the key to your cellular regeneration was found in Madagascar?
Among the jewels of Malagasy pharmacopoeia, Aloe macroclada , locally called vahona , fascinates traditional healers as much as contemporary scientists.
Today, rigorous clinical studies confirm its incredible potential to naturally stimulate the release of adult stem cells . Focus on a rare, precious plant… and one that promises longevity.

1. An endemic plant with ancient uses

Aloe macroclada is a succulent plant endemic to southern Madagascar , traditionally used:

• in fortifying syrup after illness or childbirth,

• as a liver cleanser ,

• against joint and skin pain,

• in purification rituals.

Its thick leaves contain a mucilaginous gel rich in polysaccharides , which are particularly bioactive [1].

2. A scientific breakthrough: mobilization of stem cells

In 2015, a clinical study led by Dr. Christian Drapeau (neurophysiology researcher) demonstrated for the first time that the ingestion of a standardized extract of Aloe macroclada leads to:

• rapid and transient mobilization of CD34+ and CD133+ stem cells from the bone marrow,

• a peak increase of 53% within 2 hours of consumption [2],

• with no reported side effects in participants.

These adult stem cells play a major role in tissue regeneration , slowing down aging and strengthening the immune system .

🧬 Proposed mechanism : activation of SDF-1/CXCR4 axis receptors involved in the release of circulating stem cells.

3. Alomac®: the only certified supplier

The Alomac company , co-founded by Dr. Drapeau, holds exclusive rights to the processing and distribution of this plant in North America:

• Ethical partnership with Malagasy cooperatives,

• Patented cold drying method preserving polysaccharides,

• IASC certification and FDA compliance [3].

No other laboratory to date offers a standardized and clinically validated extract of vahona .

4. Dosage, safety and synergies

✔️ Recommended Dosage (Adult)

• 1 to 2 capsules/day of Alomac® standardized extract (on an empty stomach or before a meal)

• Recommended treatment: 30 to 60 days

⚠️ Precautions

• Not recommended during pregnancy/breastfeeding without medical advice

• Risk of laxative effect if overdosed

🌿 Possible synergies

• With spirulina, DHA, AFA, saffron, resveratrol

• Integrated into an intermittent fasting , morning light or cellular rest protocol

5. Comparative table (effect on stem cells)

Natural product	Human studies?	Main effect type	Speed ​​of action	Regulatory status
Aloe macroclada (Alomac®)	✅ (Flag, 2015)	CD34+/CD133+ mobilization (53%)	In 2 hours	IASC, FDA, in NPN
AFA (Klamath)	✅ (Jensen, 2007)	CD34+ augmentation via L-selectin	In 1 hour	Current supplement
Sea buckthorn	✅ (Jensen, 2019)	CD45dim CD34+ mobilization (polyphenols)	In 1–3 hours	Little standardized
Fucoidan (brown algae)	🟡 (preclinical)	Activation via CXCR4	Slower	Not standardized
Raw honey (polyphenols)	🟡 (in vitro)	Indirect stimulation	Variable	Functional food
Resveratrol	✅ (Baur et al., 2006)	Activates sirtuins, improves stem cell survival	Average	Recognized supplement

Conclusion

Aloe macroclada is not a fad: it is a bridge between a thousand-year-old tradition and modern biotechnologies .
Its ability to mobilize adult stem cells within hours makes it a prime candidate for anyone seeking vitality, natural repair and active longevity.

At Vāhana , we believe that this plant could be part of the longevity protocols of the future , in synergy with other tools from nature and validated by science.

References

[1] Mioty Voajanahary (2022). Traditional medicinal uses of Aloe macroclada in Madagascar . miotyvoajanahary.com
[2] Drapeau, C., Benson, KF, et al. (2015). Aloe macroclada from Madagascar triggers transient bone marrow stem cell mobilization . Journal of Stem Cell Research & Therapy , 5(6):287. PDF
[3] Alomac (2024). Standardization, transformation and regulation of vahona gel . alomac.com
[4] Baur, JA et al. (2006). Resveratrol improves health and survival of mice on a high-calorie diet . Nature , 444, 337–342.