Aloe Macroclada : la régénération ‘made in’ Madagascar ?

Aloe Macroclada: regeneration 'made in' Madagascar?

⏱️ Temps de lecture : environ 5 minutes

Summary

What if the key to your cellular regeneration was found in Madagascar?
Among the jewels of Malagasy pharmacopoeia, Aloe macroclada , locally called vahona , fascinates traditional healers as much as contemporary scientists.
Today, rigorous clinical studies confirm its incredible potential to naturally stimulate the release of adult stem cells . Focus on a rare, precious plant… and one that promises longevity.

1. An endemic plant with ancient uses

An endemic species is one that exists only in a specific region and nowhere else. This is the case of the Vahona, which only grows naturally in southern Madagascar.

For generations it has been used:

  • in fortifying syrup after illness or childbirth,
  • as a liver cleanser ,
  • against joint and skin pain ,
  • in purification rituals .

Its thick leaves contain a mucilaginous gel rich in polysaccharides , which are particularly bioactive [1].

2. A scientific breakthrough: mobilization of stem cells

In 2015, a clinical study led by Dr. Christian Drapeau (neurophysiology researcher) demonstrated for the first time that the ingestion of a standardized extract of Aloe macroclada leads to:

  • rapid and transient mobilization of CD34+ and CD133+ stem cells from the bone marrow,
  • a peak increase of 53% within 2 hours of consumption [2],
  • with no reported side effects in participants.

These adult stem cells play a major role in tissue regeneration , slowing down aging and strengthening the immune system .

🧬 What exactly are these stem cells?

CD34+: hematopoietic stem cells, at the origin of all blood cells and the immune system.

CD133+: immature progenitor stem cells, capable of differentiating into several lineages, notably vascular or neuronal.

👉 These cells circulate in the blood like emergency responders on standby. When a tissue sends a distress signal (inflammation, injury), they detect it thanks to the SDF-1/CXCR4 axis (a true biological GPS) and migrate to the damaged area to participate in repair.

And why would we want to have more stem cells in circulation?

Because these cells are directly involved in:

  • tissue renewal (skin, muscles, vessels),
  • support of the immune system,
  • repair after stress or injury,
  • and slowing down the effects of aging by maintaining natural regenerative capacities.

In short, more stem cells available in the blood = more “building blocks” that the body can direct where it needs them.

3. Alomac®: the only certified supplier

The Alomac company , co-founded by Dr. Drapeau, holds exclusive rights to the processing and distribution of this plant in North America:

  • Ethical partnership with Malagasy cooperatives,
  • Patented cold drying method preserving polysaccharides,
  • IASC certification and FDA compliance [3] .

No other laboratory to date offers a standardized and clinically validated extract of vahona .

4. Dosage, safety and synergies

✔️ Recommended Dosage (Adult)

1 to 2 tablets/day of Alomac® standardized extract (on an empty stomach or before a meal)

Recommended treatment: 30 to 60 days

⚠️ Precautions

Not recommended during pregnancy/breastfeeding without medical advice

Risk of laxative effect if overdosed

🌿 Possible synergies

With spirulina, DHA, AFA, saffron, resveratrol

Mobilizing more cells is interesting, but we also need to give them a clear signal to guide them:

  • AFA (blue-green algae, Klamath): also mobilizes CD34+ cells via a complementary mechanism.
  • DHA (omega-3): supports cell integration into membranes and neuronal regeneration.
  • Saffron: promotes neuronal survival and modulates inflammatory signals.
  • Resveratrol: Activates sirtuins, which prolong cell survival.
  • Practices such as intermittent fasting or early morning light: enhance the expression of biological signals that guide stem cells to tissues in need.

👉 The key: Aloe macroclada mobilizes, synergies guide and optimize.

5. Comparative table (effect on stem cells)

Natural product Human studies? What we observed How long does it take? Regulatory status / availability
Aloe macroclada (Alomac®) ✅ Yes (Flag, 2015) Significantly increases the number of CD34+ and CD133+ stem cells (+53%) About 2 hours IASC, FDA
AFA (Klamath) ✅ Yes (Jensen, 2007) Also promotes the circulation of CD34+ cells (via another mechanism: via L-selectin) About 1 hour Current supplement
Sea buckthorn ✅ Yes (Jensen, 2019) Polyphenols mobilize certain circulating stem cells: CD45dim CD34+ mobilization About 1–3 hours Little standardized
Fucoidan (brown algae) 🟡 Preclinical studies Activates the CXCR4 pathway linked to regeneration signals Slower Not standardized
Raw honey (polyphenols) 🟡 In vitro studies Some polyphenols indirectly stimulate Variable Functional food
Resveratrol ✅ Yes (Baur et al., 2006) Activates longevity genes (sirtuins), improves stem cell survival Moderate effect Recognized supplement

Conclusion

Aloe macroclada is not a fad: it is a bridge between a thousand-year-old tradition and modern biotechnologies .

Its ability to mobilize adult stem cells within hours makes it a prime candidate for anyone seeking vitality, natural repair and active longevity.

At Vāhana , we believe that this plant could be part of the longevity protocols of the future , in synergy with other tools from nature and validated by science.

References

[1] Mioty Voajanahary (2022). Traditional medicinal uses of Aloe macroclada in Madagascar .

[2] Drapeau, C., Benson, KF, et al. (2015). Aloe macroclada from Madagascar triggers transient bone marrow stem cell mobilization . Journal of Stem Cell Research & Therapy , 5(6):287.

[3] Alomac (2024). Standardization, transformation and regulation of vahona gel .

[4] Baur, JA et al. (2006). Resveratrol improves health and survival of mice on a high-calorie diet . Nature , 444, 337–342.

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